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Morphines are the strongest form of medication used to treat pain. Opioids work by attaching to opioid receptors, which are found in many areas of the body, including the brain, spinal cord, and gastrointestinal tract. An opioid attaches to the receptor, which reduces the transmission of pain messages to the brain, reducing pain. Opioids are used to treat moderate to severe pain that is not well managed with other pain medications. They do not treat the underlying cause of the pain. If a cancer is causing the pain, the cancer treatment is aimed at reducing the pain.