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1-pentyl-3-(1-naphthoyl)indole (also called am-678 and jwh-018) is a full agonist synthetic cannabinoid first synthesized by organic chemist john w. huffman. it gained popularity in late 2008 when german chemists found it as a chemical within the popular synthetic cannabis blend spice, which had been sold in numerous countries around the world since 2002. Cannabinoids are commonly smoked or vaporized to achieve a quick onset of effects and rapid offset. jwh-018 is orally active when dissolved in a lipid, which can increase the duration significantly. like other cannabinoids, it is insoluble in water but dissolves in ethanol and lipids. Unlike cannabis, the chronic abuse of synthetic cannabinoids has been associated with multiple health effects and toxicity in general but JWH Helps For Depression, Anxiety, Disorders, Sleeplessness.

 

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JWH-018 (1-pentyl-3-(1-naphthoyl)indole) or AM-678 is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. It produces effects in animals similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products that in some countries are sold legally as “incense blends”. As a full agonist at both the CB1 and CB2 cannabinoid receptors, this chemical compound is classified as an analgesic medication. The analgesic effects of cannabinoid ligands, mediated by CB1 receptors are well established in treatment of neuropathic pain, as well as cancer pain and arthritis. These compounds work by mimicking the body’s naturally-produced endocannabinoid hormones such as 2-AG and anandamide (AEA), which are biologically active and can exacerbate or inhibit nerve signaling. As the cause is poorly understood in chronic pain states, more research and development must be done before the therapeutic potential of this class of biologic compounds can be realized.

 

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jwh-018, or naphthalen-1-yl-(1-pentylindol-3-yl)methanone, is a synthetic cannabinoid containing a substituted indole structure. this indole core is shared with other cannabinoid substances including pb-22, 5f-pb-22, jwh-018, and am2201. jwh-018 is substituted at r1 with a pentyl chain. additionally, the indole core is substituted at r3 with a carbonyl group which is also bonded to a napthalene moeity. napthalene is a bicyclic structure of two fused benzene rings. this carbonyl bridge of jwh-018 classifies it as a ketone. jwh-018 is an analog of thj-018, in which the core indazole structure is substituted with an indole base. jwh 018 incense, herbal incense with jwh-018 for sale, how to make herbal incense with jwh-018, jwh-018 incense, how to make jwh 018 incense, synthetic cannabinoid spray, buy synthetic cannabinoid spray, what do i combine with synthetic cannabinoid to make a spray. K2 synthetic cannabinoid, K2 synthetic cannabinoid, buy synthetic cannabinoid chemicals.

 

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jwh-018 is a full agonist of both the cb1 and cb2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nm at cb1 and 2.94 ± 2.65 nm at cb2. however, the role of these interactions and how it results in the cannabinoid high experience continues to remain elusive. Jwh 018 in spice, jwh 018 spice buy, buy jwh 018 spice, what company produced jwh-018 for spice, how to make spice now that jwh 018 is banned, jwh 018 spice, does diablo spice have jwh-018, how much jwh-018 is in spice, jwh 018 spice for sale, t drogen/download/analyse- the-phar-spice-jwh-018.pdf, spice with jwh-018, jwh-018 is spice?, jwh 018 spice recipe, jwh-018 spice, jwh 018 spice 2015, diy, jwh, jwh-018, jwh-073, k2, legal bud, ryo, spice, stealth, synthetic, buy synthetic cannabinoid chemicals, incense smoke for sale, herbal smoke shop near me, synthetic incense review, best herbal incense website 2020, potpourri incense wholesale, herbal incense wiki, incense spice for sale, herbal incense bags wholesale, k2 herb store, code black herbal incense, wtf herbal incense review, bizarro liquid incense, how to make spice incense, herbal incense blend, best herbal incense sites, herbal incense direct, herbal incense websites, herbal incense sticks, diablo incense buy online, best herbal highs, herbal incense overnight shipping, herbal incense bulk, kush herbal incense, herbal incense houston, herbal insence, smoking incense side effects, herbal incense on sale, incense effects, super nova herbal incense, incense herbal smoke, herbal incense 2017, liquid herbal incense sample, buy liquid herbal incense, cloud 9 liquid incense, bizzaro synthetic weed, best herbal incense high, mr kosh herbal incense, spice incense for sale cheap, mr nice guy incense for sale, how to make liquid incense, best place to buy herbal incense, k2 herbal incense for sale, cheap incense online, botanical incense for sale, liquid incense oil, liquid incense for sale, dzl incense, herbal incense 2019, cheap herbal potpourri, is herbal incense legal.

 

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Buy JWH-018 online. JWH-018 is a synthetic cannabinoid found in several versions of the herbal mixture “Spice.” Illicit use of this Spice cannabinoid centers on its psychoactive effects which mimic those of Δ9-THC in cannabis. While considerably more potent than similar amounts of cannabis, JWH-018 also presents significant challenges for detection by typical Δ9-THC testing assays.

In July, 2009, the US Drug Enforcement Agency (DEA) listed JWH-018 on its Drugs and Chemicals of Concern list. In addition to reported seizures of Spice in Ohio and Florida, several states have passed legislative action restricting the sale or possession of JWH-018 including Alabama, Arkansas, Georgia, Kansas, Kentucky, North Dakota, and Tennessee.

 

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